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1

Augmented renal clearance, low β-lactam concentrations and clinical outcomes in the critically ill: An observational prospective cohort study

Huttner, Angela, Von Dach, Elodie, Renzoni, Adriana, Huttner, Benedikt D., Affaticati, Mathieu, Pagani, Leonardo, Daali, Yousef, Pugin, Jerôme, Karmime, Abderrahim, Fathi, Marc, Lew, Daniel, Harbarth,

Journal:

International Journal of Antimicrobial Agents

Année:

2015

Langue:

english

Fichier:

PDF, 594 KB

english, 2015

2

Cytokine-mediated inflammation in acute lung injury

Richard B Goodman, Jérôme Pugin, Janet S Lee, Michael A Matthay

Journal:

Cytokine & Growth Factor Reviews

Année:

2003

Langue:

english

Fichier:

PDF, 269 KB

english, 2003

3

Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study

Laurent Spahr, Laura Rubbia-Brandt, Jean-Louis Frossard, Emile Giostra, Anne-Laure Rougemont, Jérôme Pugin, Maria Fischer, Hanspeter Egger, Antoine Hadengue

Journal:

Journal of Hepatology

Année:

2002

Langue:

english

Fichier:

PDF, 318 KB

english, 2002

4

How tissue injury alarms the immune system and causes a systemic inflammatory response syndrome

Journal:

Annals of Intensive Care

Année:

2012

Langue:

english

Fichier:

PDF, 421 KB

english, 2012

5

Diagnosis of Ventilator-associated Pneumonia by Bacteriologic Analysis of Bronchoscopic and Nonbronchoscopic “Blind” Bronchoalveolar Lavage Fluid

Pugin, Jérôme, Auckenthaler, Raymond, Mili, Nabil, Janssens, Jean-Paul, Lew, P. Daniel, Suter, Peter M.

Journal:

American Review of Respiratory Disease

Année:

1991

Langue:

english

Fichier:

PDF, 978 KB

english, 1991

6

Is Dressler Syndrome Dead?

Bendjelid, Karim, Pugin, Jérôme

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 94 KB

english, 2004

7

Activation of human macrophages by mechanical ventilation in vitro

Pugin, Jérôme, Dunn, Irène, Jolliet, Philippe, Tassaux, Didier, Magnenat, Jean-Luc, Nicod, Laurent P., Chevrolet, Jean-Claude

Journal:

American journal of physiology. Lung cellular and molecular physiology

Année:

1998

Langue:

english

Fichier:

PDF, 364 KB

english, 1998

8

The lectin-like domain of tumor necrosis factor-α increases membrane conductance in microvascular endothelial cells and peritoneal macrophages

Marusa Hribar, Alain Bloc, F. Gisou Van der Goot, Lucie Fransen, Patrick De Baetselier, Georges E. Grau, Horst Bluethmann, Michael A. Matthay, Yves Dunant, Jérôme Pugin, Rudolf Lucas

Journal:

European Journal of Immunology

Année:

1999

Langue:

english

Fichier:

PDF, 111 KB

english, 1999

9

Immune monitoring of patients with septic shock by measurement of intraleukocyte cytokines

Thierry Fumeaux, Julien Dufour, Sabine Stern, Jérôme Pugin

Journal:

Intensive Care Medicine

Année:

2004

Langue:

english

Fichier:

PDF, 237 KB

english, 2004

10

Influence of positive end-expiratory pressure (PEEP) on histopathological and bacteriological aspects of pneumonia during low tidal volume mechanical ventilation

Pierre Emmanuel Charles, Laurent Martin, Manuel Etienne, Delphine Croisier, Lionel Piroth, Catherine Lequeu, Jerome Pugin, Henri Portier, Pascal Chavanet

Journal:

Intensive Care Medicine

Année:

2004

Langue:

english

Fichier:

PDF, 495 KB

english, 2004

11

Is the measurement of monocytes HLA-DR expression useful in patients with sepsis?

Thierry Fumeaux, Jérôme Pugin

Journal:

Intensive Care Medicine

Année:

2006

Langue:

english

Fichier:

PDF, 59 KB

english, 2006

12

Hemodynamics in experimental gastric juice induced aspiration pneumonitis

Alain Fraisse, Fabienne Bregeon, Stéphane Delpierre, Jean Gaudart, Marie José Payan, Jérome Pugin, Laurent Papazian

Journal:

Intensive Care Medicine

Année:

2007

Langue:

english

Fichier:

PDF, 298 KB

english, 2007

13

Dear SIRS, the concept of “alarmins” makes a

Journal:

Intensive Care Medicine

Année:

2008

Langue:

english

Fichier:

PDF, 71 KB

english, 2008

14

Profiling genes in the ICU: Are we there yet?

Journal:

Intensive Care Medicine

Année:

2008

Langue:

english

Fichier:

PDF, 67 KB

english, 2008

15

Granulocyte colony-stimulating factor (G-CSF) downregulates its receptor (CD114) on neutrophils and induces gelatinase B release in humans

Bernd Jilma, Nicole Hergovich, Monika Homoncik, Petra Jilma-Stohlawetz, Claudia Kreuzer, Hans-Georg Eichler, Maria Zellner, Jerome Pugin

Journal:

British Journal of Haematology

Année:

2000

Langue:

english

Fichier:

PDF, 312 KB

english, 2000

16

10.1038/72262

Calandra, Thierry, Echtenacher, Bernd, Roy, Didier Le, Pugin, Jérôme, Metz, Christine N., Hültner, Lothar, Heumann, Didier, Männel, Daniela, Bucala, Richard, Glauser, Michel P.

Journal:

Nature Medicine

Année:

2000

Langue:

english

Fichier:

PDF, 174 KB

english, 2000

17

Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis

Stephan Harbarth, Jorge Garbino, Jérome Pugin, Jacques A Romand, Daniel Lew, Didier Pittet

Journal:

The American Journal of Medicine

Année:

2003

Langue:

english

Fichier:

PDF, 84 KB

english, 2003

18

Membrane interaction of TNF is not sufficient to trigger increase in membrane conductance in mammalian cells

F.Gisou van der Goot, Jérôme Pugin, Marusa Hribar, Lucie Fransen, Yves Dunant, Patrick De Baetselier, Alain Bloc, Rudolf Lucas

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 179 KB

english, 1999

19

Conventional mechanical ventilation of healthy lungs induced pro-inflammatory cytokine gene transcription

Fabienne Brégeon, Antoine Roch, Stéphane Delpierre, Eric Ghigo, Amapola Autillo-Touati, Osamu Kajikawa, Thomas R Martin, Jérôme Pugin, Henry Portugal, Jean-Pierre Auffray, Yves Jammes

Journal:

Respiratory Physiology & Neurobiology

Année:

2002

Langue:

english

Fichier:

PDF, 210 KB

english, 2002

20

CD14 Is a pattern recognition receptor

Jérôme Pugin, Didier Heumann, Alexander Tomasz, Vladimir V. Kravchenko, Yuzuru Akamatsu, Masahiro Nishijima, Michel Pierre Glauser, Peter S. Tobias, Richard J. Ulevitch

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 1.15 MB

english, 1994

21

Use of Procalcitonin to Shorten Antibiotic Treatment Duration in Septic Patients

Nobre, Vandack, Harbarth, Stephan, Graf, Jean-Daniel, Rohner, Peter, Pugin, Jérôme

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

2008

Langue:

english

Fichier:

PDF, 164 KB

english, 2008

22

Mild-stretch mechanical ventilation upregulates toll-like receptor 2 and sensitizes the lung to bacterial lipopeptide

Pierre-Emmanuel Charles, Pierre Tissières, Davide Saber Barbar, Delphine Croisier, Julien Dufour, Irène Dunn-Siegrist, Pascal Chavanet, Jérôme Pugin

Journal:

Critical Care (BioMed Central)

Année:

2011

Langue:

english

Fichier:

PDF, 651 KB

english, 2011

23

Epoetin administrated after cardiac surgery: effects on renal function and inflammation in a randomized controlled study

de Seigneux, Sophie, Ponte, Belen, Weiss, Lucien, Pugin, Jérôme, Romand, Jacques, Martin, Pierre-Yves, Saudan, Patrick

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 350 KB

english, 2012

24

Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood

Spahr, Laurent, Rubbia-Brandt, Laura, Pugin, Jérôme, Giostra, Emile, Frossard, Jean-Louis, Borisch, Bettina, Hadengue, Antoine

Journal:

Journal of Hepatology

Année:

2001

Langue:

english

Fichier:

PDF, 237 KB

english, 2001

25

Concept and Demonstration of Individual Probe Actuation in Two-Dimensional Parallel Atomic Force Microscope System

Akiyama, Terunobu, Aeschimann, Laure, Chantada, Laura, de Rooij, Nico. F., Heinzelmann, Harry, Herzig, Hans P., Manzardo, Omar, Meister, André, Polesel-Maris, Jérôme, Pugin, Raphaël, Staufer, Urs, Vet

Journal:

Japanese Journal of Applied Physics

Année:

2007

Langue:

english

Fichier:

PDF, 478 KB

english, 2007

26

Cytokine Balance in the Lungs of Patients with Acute Respiratory Distress Syndrome

PARK, WILLIAM Y., GOODMAN, RICHARD B., STEINBERG, KENNETH P., RUZINSKI, JOHN T., RADELLA, FRANK, PARK, DAVID R., PUGIN, JEROME, SKERRETT, SHAWN J., HUDSON, LEONARD D., MARTIN, THOMAS R.

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

2001

Langue:

english

Fichier:

PDF, 136 KB

english, 2001

27

Normal Responses to Injury Prevent Systemic Inflammation and Can Be Immunosuppressive

MUNFORD, ROBERT S., PUGIN, JÉRÔME

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

2001

Langue:

english

Fichier:

PDF, 144 KB

english, 2001

28

Diagnostic Value of Procalcitonin, Interleukin-6, and Interleukin-8 in Critically Ill Patients Admitted with Suspected Sepsis

HARBARTH, STEPHAN, HOLECKOVA, KATARINA, FROIDEVAUX, CÉLINE, PITTET, DIDIER, RICOU, BARA, GRAU, GEORGES E., VADAS, LASZLO, PUGIN, JÉRÔME

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

2001

Langue:

english

Fichier:

PDF, 109 KB

english, 2001

29

Hydrocarbyl derivatives of dppm- or dppa-bridged alkoxysilyl heterobimetallic Fe–Pd complexes and CO insertion reactions. Crystal structures of [(OC)3{(MeO)3Si}Fe(μ-dppm)Pd(8-mq)] (dppm = Ph2PCH2PPh2), [(OC)3Fe{μ-Si(OMe)2(OMe)}(μ-dppa)PdCl] and [(OC)3Fe{μ-Si(OMe)2(OMe)}(μ-dppa)PdPh] (dppa = Ph2PNHPPh2) †

Braunstein, Pierre, Durand, Jérôme, Kickelbick, Guido, Knorr, Michael, Morise, Xavier, Pugin, Raphael, Tiripicchio, Antonio, Ugozzoli, Franco

Journal:

Journal of the Chemical Society Dalton Transactions

Année:

1999

Langue:

english

Fichier:

PDF, 331 KB

english, 1999

30

Adrenomedullin: a vasodilator to treat sepsis?

Journal:

Critical Care (BioMed Central)

Année:

2014

Langue:

english

Fichier:

PDF, 118 KB

english, 2014

31

Lipopolysaccharide Activation of Human Endothelial and Epithelial Cells is Mediated by Lipopolysaccharide-Binding Protein and Soluble CD14

Jerome Pugin, Cornelia-C. Schurer-Maly, Didier Leturcq, Ann Moriarty, Richard J. Ulevitch and Peter S. Tobias

Journal:

Proceedings of the National Academy of Sciences

Année:

1993

Langue:

english

Fichier:

PDF, 1000 KB

english, 1993

32

Is Anti–Tumor Necrosis Factor Therapy Associated with Increased Mortality in Patients with Severe Sepsis Caused by Pneumonia?

Harbarth, Stephan, Garbino, Jorge, Pittet, Didier, Pugin, Jérome

Journal:

The Journal of Infectious Diseases

Année:

2004

Langue:

english

Fichier:

PDF, 40 KB

english, 2004

33

Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial

Stucker, Fabien, Ponte, Belen, Tataw, James, Martin, Pierre-Yves, Wozniak, Hannah, Pugin, Jérome, Saudan, Patrick

Journal:

Critical Care (BioMed Central)

Année:

2015

Langue:

english

Fichier:

PDF, 443 KB

english, 2015

34

Pivotal Involvement of Fcγ Receptor IIA in the Neutralization of Lipopolysaccharide Signaling via a Potent Novel Anti-TLR4 Monoclonal Antibody 15C1

Dunn-Siegrist, Irene, Leger, Olivier, Daubeuf, Bruno, Poitevin, Yves, Dépis, Fabien, Herren, Suzanne, Kosco-Vilbois, Marie, Dean, Yann, Pugin, Jérôme, Elson, Greg

Journal:

Journal of Biological Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 1021 KB

english, 2007

35

Oropharyngeal Decontamination Decreases Incidence of Ventilator-Associated Pneumonia

Pugin, Jérôme, Auckenthaler, Raymond, Lew, Daniel P., Suter, Peter M.

Journal:

JAMA The Journal of the American Medical Association

Année:

1991

Langue:

english

Fichier:

PDF, 999 KB

english, 1991

36

Oral Decontamination and Ventilator-Associated Pneumonia-Reply

Pugin, Jérôme

Journal:

JAMA The Journal of the American Medical Association

Année:

1991

Langue:

english

Fichier:

PDF, 206 KB

english, 1991

37

Human Neutrophils Secrete Gelatinase B In Vitro and In Vivo in Response to Endotoxin and Proinflammatory Mediators

Pugin, Jérôme, Widmer, Marie-Claude, Kossodo, Sylvie, Liang, Chi-Ming, Preas, H. L., Suffredini, Anthony F.

Journal:

American Journal of Respiratory Cell and Molecular Biology

Année:

1999

Langue:

english

Fichier:

PDF, 630 KB

english, 1999

38

Role of MAP Kinase Activation in Interleukin-8 Production by Human BEAS-2B Bronchial Epithelial Cells Submitted to Cyclic Stretch

Oudin, Séverine, Pugin, Jérôme

Journal:

American Journal of Respiratory Cell and Molecular Biology

Année:

2002

Langue:

english

Fichier:

PDF, 165 KB

english, 2002

39

Role of Interleukin-10 in the Intracellular Sequestration of Human Leukocyte Antigen-DR in Monocytes during Septic Shock

Fumeaux, Thierry, Pugin, Jérôme

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

2002

Langue:

english

Fichier:

PDF, 279 KB

english, 2002

40

Compartmentalization of the Inflammatory Response during Acute Pancreatitis

Dugernier, Thierry L., Laterre, Pierre-François, Wittebole, Xavier, Roeseler, Jean, Latinne, Dominique, Reynaert, Marc S., Pugin, Jérôme

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

2003

Langue:

english

Fichier:

PDF, 140 KB

english, 2003

41

Cyclic Stretch of Human Lung Cells Induces an Acidification and Promotes Bacterial Growth

Pugin, Jérôme, Dunn-Siegrist, Irène, Dufour, Julien, Tissières, Pierre, Charles, Pierre-Emmanuel, Comte, Rachel

Journal:

American Journal of Respiratory Cell and Molecular Biology

Année:

2008

Langue:

english

Fichier:

PDF, 298 KB

english, 2008

42

Pulmonary Edema Fluid from Patients with Acute Lung Injury Augments In Vitro Alveolar Epithelial Repair by an IL-1 β -dependent Mechanism

GEISER, THOMAS, ATABAI, KAMRAN, JARREAU, PIERRE-HENRI, WARE, LORRAINE B., PUGIN, JÉRÔME, MATTHAY, MICHAEL A.

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

2001

Langue:

english

Fichier:

PDF, 151 KB

english, 2001

43

Balance between Proinflammatory Cytokines and Their Inhibitors in Bronchial Lavage from Patients with Status Asthmaticus

TILLIE-LEBLOND, ISABELLE, PUGIN, JÉRÔME, MARQUETTE, CHARLES-HUGO, LAMBLIN, CATHERINE, SAULNIER, FABIENNE, BRICHET, ANNE, WALLAERT, BENOIT, TONNEL, ANDRÉ-BERNARD, GOSSET, PHILIPPE

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

1999

Langue:

english

Fichier:

PDF, 88 KB

english, 1999

44

CC Chemokines and Interleukin-5 in Bronchial Lavage Fluid from Patients with Status Asthmaticus

TILLIE-LEBLOND, ISABELLE, HAMMAD, HAMIDA, DESURMONT, SOPHIE, PUGIN, JÉRÔME, WALLAERT, BENOÎT, TONNEL, ANDRÉ-BERNARD, GOSSET, PHILIPPE

Journal:

American Journal of Respiratory and Critical Care Medicine

Année:

2000

Langue:

english

Fichier:

PDF, 329 KB

english, 2000

45

Characteristics of an ideal nebulized antibiotic for the treatment of pneumonia in the intubated patient

Bassetti, Matteo, Luyt, Charles-Edouard, Nicolau, David P., Pugin, Jérôme

Journal:

Annals of Intensive Care

Année:

2016

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2016

46

The role of MD-2 in the opsonophagocytosis of Gram-negative bacteria

Tissières, Pierre, Pugin, Jérôme

Journal:

Current Opinion in Infectious Diseases

Année:

2009

Langue:

english

Fichier:

PDF, 161 KB

english, 2009

47

Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia

Pastor, Catherine M., Pugin, Jérôme, Kwak, Brenda, Chanson, Marc, Mach, François, Hadengue, Antoine, Frossard, Jean Louis

Journal:

Critical Care Medicine

Année:

2004

Langue:

english

Fichier:

PDF, 880 KB

english, 2004

48

Molecular mechanisms of lung cell activation induced by cyclic stretch

Pugin, Jérôme

Journal:

Critical Care Medicine

Année:

2003

Langue:

english

Fichier:

PDF, 466 KB

english, 2003

49

The impact of mechanical ventilation on the moxifloxacin treatment of experimental pneumonia caused by Streptococcus pneumoniae

Charles, Pierre Emmanuel, Etienne, Manuel, Croisier, Delphine, Piroth, Lionel, Lequeu, Catherine, Pugin, Jerome, Portier, Henri, Chavanet, Pascal

Journal:

Critical Care Medicine

Année:

2005

Langue:

english

Fichier:

PDF, 557 KB

english, 2005

50

Pseudomembranous colitis

Spahr, Laurent, de Saussure, Philippe, Felley, Christian, Pugin, Jérôme, Hadengue, Antoine

Journal:

European Journal of Gastroenterology & Hepatology

Année:

1999

Fichier:

PDF, 227 KB

1999